Sidney Hopps has over 18 years experience in international financial markets in equity and equity derivatives securitization and sales in New York, Chicago, London, and Paris.
Prior to co-founding Adze Biotechnology, Mr. Hopps was the CEO of Jivana Biotechnology, a spin-out of the University of Illinois - Chicago, which is focused on gene therapy against solid tumors.
Mr Hopps spent many years working with biotechnology companies in the public markets while at UBS and First Albany Corp. Most recently, Mr Hopps was a partner in Global Diversified Fund Management. Mr Hopps is responsible for developing the firm's legal and regulatory pathways, capital raising, drug delivery technology alliances, and managing pre clinical trials.
Mr Hopps is a member of 700 for Science, a collaborative community dedicated to bringing early stage biotechnologies to life.
The laboratory of Michael A. Barry, Ph.D., is working to use genes and viruses to treat a set of very difficult diseases. Because these agents are as adaptable as DNA itself, Dr. Barry and his team can apply these "drugs" against a variety of diseases by fine-tuning which cells they target and avoiding or activating the immune system. This work falls into three areas: gene therapy, gene-based vaccines and anti-cancer virotherapy.
For gene therapy and vaccines, Dr. Barry and his colleagues want to deliver genes to cells and have the cells survive. For this reason, they use tamed versions of viruses to deliver genes for gene therapy or gene-based vaccines. For cancer therapy, the goal is to kill cells. For this application, they modify the viruses to still kill cancer cells, but protect normal cells. These anti-cancer viruses have the appeal that they can be thought of as "self-amplifying" drugs because each cancer cell that gets killed can in turn produce thousands of new anti-cancer viruses that can spread to other cancer sites. Therefore, these self-amplifying drugs can infect one cancer site and spread. Dr. Barry's lab therefore hopes they may be useful to treat cancers that have spread or have metastasized locally or throughout the body.
In recent years, the lab has tested a number of viruses against many types of cancer, including prostate, breast, ovarian and B cell cancers. Interestingly, they have found that different viruses actually appear to have different "appetites" for killing different types of cancers. Based on this, the lab is moving several viruses toward the clinic, with viruses for prostate cancer and B cell lymphoma being closest to clinical translation.
Ken Templin is a retired Business Resource Manager from Caterpillar where he spent almost 37 years working in both the engine and machinery businesses in multiple locations throughout the world.
More recently, he is consulting small and growing businesses in a variety of business segments.
Ken’s Caterpillar career included various ﬁnancial staﬀ, supervisory and manager positions supporting both plant operations and corporate oﬃces.
His accomplishments included deploying 6 Sigma as a lead champion for one of Cat’s business units, acquiring businesses and forming new strategic businesses, working on a special team to develop enterprise wide realignment issues for Cat’s Execuive Oﬃce, guiding the installaion of a multi-‐plant Enterprise Resource Planning system and leading the development of a global ﬁnance transformation strategy that is enabling the way to global common processes supported by a single integrated system.
Mr. Sage, a registered patent attorney since 1993 and founder of Kalamazoo, Mich.-based Hueschen & Sage, PLLC, specializes in advising innovator pharmaceutical, dermatological and fine chemical companies in portfolio development, prosecution, management, agency registration, enforcement and partnering.
Mr. Sage graduated from Kalamazoo College with a BA in Biology in 1986, and from Loyola University in Chicago with a JD in 1992.
He started his career as a biochemist with The Upjohn Company, conducting pharmacological research on putative Alzheimer’s compounds.