Systemically-deliverable, retargeted oncolytic viruses that deliver immune stimulatory and immune evasion blocking proteins to tumors.
What we do
Adze oncolytic vectors selectively target and kill cancer cells.
Adze Biotechnology's self-amplifying oncolytic viruses target and kill local and disseminated cancer cells, leaving healthy cells unaffected.
Our vectors also act as platforms to safely deliver potent immunostimulatory and immune evasion blocking proteins into tumors.
Our oncolytic vectors kill cancer cells directly, exposing cancer antigens to the immune system, while the immunotherapy payloads stimulate the patient's own immune response.
After the first cancer cells are executed, local and distant cancer cells are infected and the oncolytic and immunotherapeutic wave propagates.
Our vectors also target the same immune evasion checkpoints as current therapies by delivering immune evasion blocking proteins to cancer cells.
Adze's oncolytic vectors have modified surface proteins, which allows for more versatile and potent vectors. These modifications improve macrophage evasion for increased potency at reduced dosing levels.
ADZ Single IV Dose vs Distant DU145 Prostate Tumors
Prostate Tumors - Single Injection
PD-L1 Decoy Proteins
Oncolytic vectors
Our oncolytic vectors stimulate an immune response while blocking immune evasion proteins.
Our virotherapy platform targets the same immune checkpoints as current therapies, but also kills cancer cells and exposes cancer antigens to the immune system.
Proprietary modifications to our viral particles help escape circulating macrophages
for improved potency.
Oncolytic vectors
Genetically Modified Surface Proteins Allow For Systemic And Intra-tumoral Delivery
ADZ Hexon proteins are designed to evade scavenger receptors in the liver's Kupffer cells. These modifications allow for greater systemic anti-cancer therapy activity.
Chemically Shielded ADZ Single IV Treatment LNCap Tumors
Chemically Shielded ADZ Single IV Treatment LNCap Tumors
A549 lung cancer cells infected with ADZ-000/GFP
